DEVELOPMENT AND PROLIFERATION OF LYMPHOCYTES IN MICE DEFICIENT FOR BOTH INTERLEUKIN-2 AND INTERLEUKIN-4

被引：129

作者：

SADLACK, B

KUHN, R

SCHORLE, H

RAJEWSKY, K

MULLER, W

HORAK, I

机构：

[1] UNIV WURZBURG, INST VIROL & IMMUNOBIOL, D-97078 WURZBURG, GERMANY

[2] UNIV COLOGNE, INST GENET, COLOGNE, GERMANY

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1994年 / 24卷 / 01期

关键词：

INTERLEUKIN-2; INTERLEUKIN-4; DEVELOPMENT AND PROLIFERATION OF LYMPHOCYTES; CYTOKINES; KNOCK-OUT MICE;

D O I：

10.1002/eji.1830240144

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interleukin (IL)-2 and IL-4 are considered as important regulators of growth and differentiation of lymphocytes. We report that in mice made deficient for both IL-2 and IL-4 by gene targeting all major T cell subsets and B cells were normal, indicating that IL-2 and IL-4 are not essential for development of the immune system. Paradoxically, proliferation of T cells was increased in both IL-2- and IL-4-deficient homozygous mice.

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页码：281 / 284

页数：4

相关论文

共 16 条

[1] TARGETED CORRECTION OF A MUTANT HPRT GENE IN MOUSE EMBRYONIC STEM-CELLS [J].

DOETSCHMAN, T ;

GREGG, RG ;

MAEDA, N ;

HOOPER, ML ;

MELTON, DW ;

THOMPSON, S ;

SMITHIES, O .

NATURE, 1987, 330 (6148) :576-578

[2] LYMPHOKINE CONTROL OF INVIVO IMMUNOGLOBULIN ISOTYPE SELECTION [J].

FINKELMAN, FD ;

HOLMES, J ;

KATONA, IM ;

URBAN, JF ;

BECKMANN, MP ;

PARK, LS ;

SCHOOLEY, KA ;

COFFMAN, RL ;

MOSMANN, TR ;

PAUL, WE .

ANNUAL REVIEW OF IMMUNOLOGY, 1990, 8 :303-333

[3]

Forster I, 1989, Int Immunol, V1, P321, DOI 10.1093/intimm/1.4.321

[4] KINETICS AND EFFICACY OF POSITIVE SELECTION IN THE THYMUS OF NORMAL AND T-CELL RECEPTOR TRANSGENIC MICE [J].

HUESMANN, M ;

SCOTT, B ;

KISIELOW, P ;

VONBOEHMER, H .

CELL, 1991, 66 (03) :533-540

[5] GENERATION AND ANALYSIS OF INTERLEUKIN-4 DEFICIENT MICE [J].

KUHN, R ;

RAJEWSKY, K ;

MULLER, W .

SCIENCE, 1991, 254 (5032) :707-710

[6] IMMUNE-RESPONSES IN INTERLEUKIN-2 DEFICIENT MICE [J].

KUNDIG, TM ;

SCHORLE, H ;

BACHMANN, MF ;

HENGARTNER, H ;

ZINKERNAGEL, RM ;

HORAK, I .

SCIENCE, 1993, 262 (5136) :1059-1061

[7] CYTOKINES - IS THERE BIOLOGICAL MEANING [J].

MOSMANN, TR .

CURRENT OPINION IN IMMUNOLOGY, 1991, 3 (03) :311-314

[8] PLEIOTROPY AND REDUNDANCY - T-CELL-DERIVED LYMPHOKINES IN THE IMMUNE-RESPONSE [J].

PAUL, WE .

CELL, 1989, 57 (04) :521-524

[9] THYMUS-INDEPENDENT DEVELOPMENT AND NEGATIVE SELECTION OF T-CELLS EXPRESSING T-CELL RECEPTOR-ALPHA/BETA IN THE INTESTINAL EPITHELIUM - EVIDENCE FOR DISTINCT CIRCULATION PATTERNS OF GUT-DERIVED AND THYMUS-DERIVED LYMPHOCYTES-T [J].

POUSSIER, P ;

EDOUARD, P ;

LEE, C ;

BINNIE, M ;

JULIUS, M .

JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 176 (01) :187-199

[10] ULCERATIVE COLITIS-LIKE DISEASE IN MICE WITH A DISRUPTED INTERLEUKIN-2 GENE [J].

SADLACK, B ;

MERZ, H ;

SCHORLE, H ;

SCHIMPL, A ;

FELLER, AC ;

HORAK, I .

CELL, 1993, 75 (02) :253-261