EFFECT OF CDP-CHOLINE ON COGNITION AND IMMUNE FUNCTION IN ALZHEIMERS-DISEASE AND MULTIINFARCT DEMENTIA

被引：39

作者：

CACABELOS, R

ALVAREZ, XA

FRANCOMASIDE, A

FERNANDEZNOVOA, L

CAAMANO, J

机构：

[1] Institute for CNS Disorders, Basic and Clinical Neurosciences Research Center, La Coruña

来源：

ALZHEIMERS DISEASE: AMYLOID PRECUSOR PROTEINS, SIGNAL TRANSDUCTION, AND NEURONAL TRANSPLANTATION | 1993年 / 695卷

关键词：

D O I：

10.1111/j.1749-6632.1993.tb23076.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cholinergic dysfunction present in Alzheimer's disease (AD) might be due to a specific vulnerability of cholinergic neurons linked to neurotrophic imbalance, neuroimmune impairment, and/or direct effects of beta-amyloid deposition and NET formation in ACh neurons. The presence of abnormal epitopes exposed on neuronal membranes may contribute to the activation of resting microglia initiating a neuroimmune cascade leading to cell destruction. According to this hypothesis, a multifactorial treatment in AD should produce: 1) inhibition of beta-amyloid and NPT formation; 2) restoration of neuronal membrane integrity; and 3) control of neuroimmune auto-aggression. Since interleukin-l (IL-1) is an APP gene promoter showing a progressive increase in body fluids in parallel with mental deterioration in AD patients, we have studied the effects of CDP-choline on cognition, several biological parameters, and IL-1 beta production in AD and multi-infarct dementia (MID) in order to elucidate whether this compound alone or in combination with other drugs is able to restore immune function and improve mental performance in senile dementia.

引用

页码：321 / 323

页数：3

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