SEARCH FOR ENTERIC MICROBIAL PATHOGENS IN PATIENTS WITH ULCERATIVE-COLITIS

被引：20

作者：

BROWN, WJ

HUDSON, MJ

PATRICK, S

MATTHEWS, SCW

HILL, MJ

GENT, AE

GRACE, RH

HELLIER, MD

SWARBRICK, ET

机构：

[1] PUBL HLTH LAB SERV,CTR APPL MICROBIOL & RES,DIV PATHOL,PORTON DOWN,SALISBURY SP4 0JG,WILTS,ENGLAND

[2] ROYAL HOSP WOLVERHAMPTON,WOLVERHAMPTON,ENGLAND

[3] NEW CROSS HOSP,WOLVERHAMPTON WV10 0QP,W MIDLANDS,ENGLAND

[4] PRINCESS MARGARET HOSP,SWINDON,ENGLAND

[5] ODSTOCK HOSP,PUBL HLTH LAB,SALISBURY SP2 8BJ,WILTS,ENGLAND

[6] GEN INFIRM,SALISBURY,ENGLAND

来源：

DIGESTION | 1992年 / 53卷 / 3-4期

关键词：

ULCERATIVE COLITIS; INFLAMMATORY BOWEL DISEASE; ENTERIC INFECTION; ETIOLOGY; FECES; MICROFLORA; COLONIZATION RESISTANCE; CYTOTOXIN;

D O I：

10.1159/000200985

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Microbial pathogens were sought in faeces of patients with active ulcerative colitis and again after 3 months treatment. 64 patients were examined during their first episode of ulcerative colitis and 30 with relapse of chronic disease. At presentation, bacterial pathogens were not found; 1 patient had cryptosporidiosis. In 10 patients treatment appeared to result in some loss of colonisation resistance as evidenced by colonisation with beta-haemolytic streptococci, Stapkylococcus aureus, candida and Clostridium difficile. Unidentified cytotoxic activity was present in the faeces of 4 patients at presentation and 2 patients during or after treatment. We conclude that enteric infection is an uncommon finding in patients with active ulcerative colitis.

引用

页码：121 / 128

页数：8

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