TESTOSTERONE SECRETION BY RAT, RABBIT, GUINEA-PIG, DOG, AND HAMSTER TESTES PERFUSED INVITRO - CORRELATION WITH LEYDIG-CELL MASS

被引:88
作者
EWING, LL
ZIRKIN, BR
COCHRAN, RC
KROMANN, N
PETERS, C
RUIZBRAVO, N
机构
[1] Division of Reproductive Biology, Department of Population Dynamics, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD
[2] Johns Hopkins University, School of Medicine, Baltimore, MD
[3] Department of Biology, Yale University, New Haven, CT
关键词
D O I
10.1210/endo-105-5-1135
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Testes from guinea pigs, rabbits, dogs, rats, and hamsters perfused in vitro with maximally stimulating concentrations of ovine LH released 9.76 ± 2.05, 12.80 ± 3.15, 28.94 ± 3.01, 3.18 ± 0.41, and 0.70 ± 0.12 μg testosterone (T)/h, respectively. Adjusting for differences in testicular weight did not eliminate significant (P < 0.01) species variation in testicular capacity for T secretion in response to ovine LH. Similarly, correction for Leydig cell mass, as determined by morphometric analysis, still left significant (P < 0.01) differences in the testosterone secretion rates in response to ovine LH for guinea pigs (262.5 ± 38.6 μg T/g Leydig cell), rabbits (205.5 ± 50.7 μg T/g Leydig cell), dogs (116.4 ± 14.8 jug T/g Leydig cell), rats (83.55 ± 21.80 μg T/g Leydig cell), and hamsters (18.24 ± 3.55 μg T/g Leydig cell). The data suggest that significant between-species variation of T production in response to ovine LH is not due to quantitative differences in the mass of Leydig cells. © 1979 by The Endocrine Society.
引用
收藏
页码:1135 / 1142
页数:8
相关论文
共 36 条
[1]  
BARTLETT DJ, 1962, J REPROD FERTIL, V3, P173, DOI 10.1530/jrf.0.0030173
[2]  
Bouin P, 1903, ARCH ZOOL EXP GEN, V1, P437
[3]   COMPARATIVE ABILITY OF SEMINIFEROUS TUBULES AND INTERSTITIAL TISSUE OF RAT TESTES TO SYNTHESIZE ANDROGENS FROM PROGESTERONE-4-14C IN VITRO [J].
CHRISTENSEN, AK ;
MASON, NR .
ENDOCRINOLOGY, 1965, 76 (04) :646-+
[4]   FINE STRUCTURE OF TESTICULAR INTERSTITIAL CELLS IN GUINEA PIGS [J].
CHRISTENSEN, AK .
JOURNAL OF CELL BIOLOGY, 1965, 26 (03) :911-+
[5]  
Christensen AK, 1969, GONADS, P415
[6]   TESTICULAR MATURATION IN RABBIT - SECRETION OF TESTOSTERONE, DIHYDROTESTOSTERONE, 5-ALPHA-ANDROSTAN-3-ALPHA,17-BETA-DIOL AND 5-ALPHA-ANDROSTAN-3-BETA,17-BETA-DIOL BY PERFUSED RABBIT TESTES EPIDIDYMIDES AND SPERMATOGENESIS [J].
CHUBB, C ;
EWING, L ;
IRBY, D ;
DESJARDINS, C .
BIOLOGY OF REPRODUCTION, 1978, 18 (02) :212-218
[7]  
CHUBB C, AM J PHYSL
[8]   MULTIPLE RANGE TESTS FOR CORRELATED AND HETEROSCEDASTIC MEANS [J].
DUNCAN, DB .
BIOMETRICS, 1957, 13 (02) :164-176
[9]   TESTOSTERONE AND 5-ALPHA-REDUCED ANDROGEN SECRETION BY RABBIT TESTES-EPIDIDYMIDES PERFUSED INVITRO [J].
EWING, L ;
BROWN, B ;
IRBY, DC ;
JARDINE, I .
ENDOCRINOLOGY, 1975, 96 (03) :610-617
[10]   SYNERGISTIC INTERACTION OF TESTOSTERONE AND ESTRADIOL INHIBITS PERMATOGENESIS IN RATS [J].
EWING, LL ;
DESJARDINS, C ;
IRBY, DC ;
ROBAIRE, B .
NATURE, 1977, 269 (5627) :409-410