NUCLEOSIDES AND NUCLEOTIDES .128. (2'S)-2'-DEOXY-2'-C-METHYL-5-IODOURIDINE (SMIU) AS A NOVEL POTENT ANTI-HERPES VIRUS AGENT

被引:35
作者
AWANO, H
SHUTO, S
BABA, M
KIRA, T
SHIGETA, S
MATSUDA, A
机构
[1] HOKKAIDO UNIV,FAC PHARMACEUT SCI,KITA KU,SAPPORO,HOKKAIDO 060,JAPAN
[2] FUKUSHIMA MED COLL,DEPT BACTERIOL,FUKUSHIMA 96012,JAPAN
关键词
D O I
10.1016/S0960-894X(01)80146-3
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
(2'S)-2'-deoxy-2'-C-methyl-5-halogenopyrimidine nucleosides were designed and synthesized as anti-herpes virus agents. Of these compounds, (2'S)-2'-deoxy-2'-C-methyl-5-iodouridine (SMIU, 9e) showed the greatest anti-HSV-l activity in vitro while showing no cytotoxicity. SMIU is a candidate drug for clinical treatment of herpes virus infection disease.
引用
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页码:367 / 370
页数:4
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