THE NMDA ANTAGONIST MK-801 BLOCKS LIGHT EFFECT ON MELATONIN RECEPTOR DENSITY IN RAT SUPRACHIASMATIC NUCLEI

被引：14
|
作者：
GAUER, F [1 ]
MASSONPEVET, M [1 ]
PEVET, P [1 ]
机构：
[1] UNIV STRASBOURG 1,CNRS,URA 1332,F-67000 STRASBOURG,FRANCE
来源：
NEUROSCIENCE LETTERS | 1994年 / 171卷 / 1-2期
关键词：
MELATONIN RECEPTOR; SUPRACHIASMATIC NUCLEUS; LIGHT PULSE; MK-801; NMDA RECEPTOR; PINEALECTOMY; MELATONIN;
D O I：
10.1016/0304-3940(94)90595-9
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In pinealectomized rats, melatonin receptor density in the suprachiasmatic nuclei was recently shown to be strongly decreased during the dark period. Furthermore, a one-hour long light pulse is able to reverse this dark-induced decrease. We demonstrate here that this effect of a light-pulse during night time is blocked by prior application of the NMDA receptor antagonist MK-801. These results show that the light effect on melatonin receptor density in the SCN is mediated by activation of NMDA-type receptors.
引用
收藏
页码：24 / 26
页数：3
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