SUPEROXIDE ANION-INDUCED HISTAMINE-RELEASE FROM RAT PERITONEAL MAST-CELLS

被引：0

作者：

AKAGI, M ^{[1
]}

KATAKUSE, Y ^{[1
]}

FUKUISHI, N ^{[1
]}

KAN, T ^{[1
]}

AKAGI, R ^{[1
]}

机构：

[1] OKAYAMA PREFECTURAL UNIV, FAC HLTH & WELF SCI, DEPT NUTRIT SCI, OKAYAMA 700, JAPAN

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 1994年 / 17卷 / 05期

关键词：

SUPEROXIDE ANION; HISTAMINE RELEASE; RAT MAST CELL;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We investigated the properties of superoxide anion (O2-)-induced histamine release from rat peritoneal mast cells using superoxide anion radicals obtained from potassium superoxide (KO2). KO2 elicited a rapid histamine release in a dose-dependent fashion, without lactate dehydrogenase (LDH) release. The KO2-induced release was temperature- and energy-dependent. KO2 rapidly increased the intracellular free Ca2+ concentration, accompanied by a marked increase of Ca2+-uptake. These findings indicate that the increase in intracellular Ca2+ concentration is involved in the initiation of KO2-induced histamine release, and KO, could be used as an agent of O2--induced biological reactions.

引用

页码：732 / 734

页数：3

共 14 条

[1]

AKAGI M, 1992, JPN J PHARMACOL, V58, pP306

[2] DIFFERENCES IN REQUIREMENTS AND ACTIONS OF VARIOUS HISTAMINE-RELEASING AGENTS [J].

BAXTER, JH ;

ADAMIK, R .

BIOCHEMICAL PHARMACOLOGY, 1978, 27 (04) :497-503

[3]

Bergmeyer HU, 1974, METHOD ENZYMAT AN, P574

[4]

DAMAS J, 1981, CR SOC BIOL, V175, P266

[5]

HATANO T, 1989, J MED PHARM SOC WAKA, V6, P412

[6] ANTIALLERGIC EFFECT OF EPINASTINE (WAL-801-CL) ON IMMEDIATE HYPERSENSITIVITY REACTIONS .1. ELUCIDATION OF THE MECHANISM FOR HISTAMINE-RELEASE INHIBITION [J].

KAMEI, C ;

AKAGI, M ;

MIO, M ;

KITAZUMI, K ;

IZUSHI, K ;

MASAKI, S ;

TASAKA, K .

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 1992, 14 (1-2) :191-205

[7]

LICHTENSTEIN LM, 1975, J IMMUNOL, V114, P1692

[8]

MANNAIONI PF, 1991, INT J TISSUE REACT, V13, P271

[9] PROSTAGLANDIN-H SYNTHETASE ACTIVATES XENOBIOTICS INTO FREE-RADICALS - HISTAMINE-RELEASE AND BIOCHEMICAL CHARACTERISTICS [J].

MASINI, E ;

GIANNELLA, E ;

PALMERANI, B ;

PISTELLI, A ;

GAMBASSI, F ;

MANNAIONI, PF .

INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY, 1989, 88 (1-2) :134-135

[10] XANTHINE OXIDASE-INDUCED HISTAMINE-RELEASE FROM ISOLATED RAT PERITONEAL MAST-CELLS - INVOLVEMENT OF HYDROGEN-PEROXIDE [J].

OHMORI, H ;

KOMORIYA, K ;

AZUMA, A ;

KUROZUMI, S ;

OTO, YH .

BIOCHEMICAL PHARMACOLOGY, 1979, 28 (02) :333-334

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