THE EFFECTS OF INTERFERON-ALPHA INTERFERON-BETA IN A MODEL OF RAT-HEART TRANSPLANTATION

被引：0
|
作者：
SLATER, AD
KLEIN, JB
SONNENFELD, G
OGDEN, LL
GRAY, LA
机构：
来源：
JOURNAL OF HEART AND LUNG TRANSPLANTATION | 1992年 / 11卷 / 05期
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Interferons have multiple immunologic effects. One such effect is the activation of expression of cell surface antigens. Interferon alpha/beta enhance expression of class I but not class II histocompatibility antigens. Contradictory information has been published regarding the effect of interferon-alpha/beta administration in patients with kidney transplantation. In a model of rat heart transplantation we demonstrated that administration of interferon-alpha/beta accelerated rejection in a dose-dependent fashion in the absence of maintenance cyclosporine. Animals treated with maintenance cyclosporine had evidence of increased rejection at 20 days that was resolved completely at 45 days with cyclosporine alone.
引用
收藏
页码：975 / 978
页数：4
相关论文
共 50 条
  • [1] INDUCTION OF INTERFERON-ALPHA BY INTERFERON-BETA, BUT NOT OF INTERFERON-BETA BY INTERFERON-ALPHA, IN THE MOUSE
    ASANO, M
    HAYASHI, M
    YOSHIDA, E
    KAWADE, Y
    IWAKURA, Y
    VIROLOGY, 1990, 176 (01) : 30 - 38
  • [2] ENTERIC ABSORPTION OF HUMAN INTERFERON-ALPHA AND INTERFERON-BETA IN THE RAT
    BOCCI, V
    CORRADESCHI, F
    NALDINI, A
    LENCIONI, E
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1986, 34 (1-2) : 111 - 114
  • [3] CLONING OF INTERFERON-ALPHA AND MURINE INTERFERON-BETA
    VODJANI, G
    LEROSCOUET, D
    HORTH, M
    PERRUCA, DL
    LEMAIGREDUBREUIL, Y
    TOVEY, M
    BRISON, O
    LATTA, M
    DOLY, J
    ANNALES DE VIROLOGIE, 1984, 135 (03): : 306 - 306
  • [4] DEFINITION OF IMMUNOMODULATORY EFFECTS OF INTERFERON-ALPHA, INTERFERON-BETA, AND INTERFERON-GAMMA
    BORDEN, EC
    JOURNAL OF CELLULAR BIOCHEMISTRY, 1987, : 179 - 179
  • [5] COMPARISON BETWEEN THE EFFECTS OF INTERFERON-ALPHA AND INTERFERON-BETA ON LIPID-METABOLISM
    KIOKA, K
    SO, K
    MORIYOSHI, Y
    NEBIKI, H
    OKAWA, K
    OKA, H
    YAMADA, H
    HARIHARA, S
    KUROKI, T
    KOBAYASHI, K
    GASTROENTEROLOGY, 1995, 108 (04) : A1098 - A1098
  • [6] L-CELLS REMOVE INTERFERON-BETA BUT NOT INTERFERON-ALPHA
    RAMAMURTHY, V
    FLEISCHMANN, WR
    FEDERATION PROCEEDINGS, 1985, 44 (06) : 1838 - 1838
  • [7] AGONIST AND ANTAGONIST EFFECTS OF INTERFERON-ALPHA AND INTERFERON-BETA ON ACTIVATION OF HUMAN MACROPHAGES - 2 CLASSES OF INTERFERON-GAMMA RECEPTORS AND BLOCKADE OF THE HIGH-AFFINITY SITES BY INTERFERON-ALPHA OR INTERFERON-BETA
    YOSHIDA, R
    MURRAY, HW
    NATHAN, CF
    JOURNAL OF EXPERIMENTAL MEDICINE, 1988, 167 (03) : 1171 - 1185
  • [8] DIFFERING CELL RESPONSES TO INTERFERON-GAMMA AND TO INTERFERON-ALPHA AND INTERFERON-BETA
    WALLACH, D
    FELLOUS, M
    SCHLUSSEL, R
    REVEL, M
    ISRAEL JOURNAL OF MEDICAL SCIENCES, 1982, 18 (06): : 21 - 21
  • [9] EFFECTS OF INTERFERON-ALPHA, INTERFERON-BETA, AND INTERFERON-GAMMA ON HUMAN INTERLEUKIN-2 PRODUCTION
    ROSZTOCZY, I
    SIROKI, O
    BELADI, I
    JOURNAL OF INTERFERON RESEARCH, 1986, 6 (05): : 581 - 589
  • [10] Shared and Unique Features of Human Interferon-Beta and Interferon-Alpha Subtypes
    Wittling, Megen C.
    Cahalan, Shannon R.
    Levenson, Eric A.
    Rabin, Ronald L.
    FRONTIERS IN IMMUNOLOGY, 2021, 11
12345