PRODUCTION OF A TRANSFORMING GROWTH FACTOR-BETA-LIKE GROWTH-FACTOR BY RSV-TRANSFORMED RAT CEREBRAL MICROVASCULAR ENDOTHELIAL-CELLS

被引：8

作者：

MOORADIAN, DL ^{[1
]}

DIGLIO, CA ^{[1
]}

机构：

[1] WAYNE STATE UNIV,SCH MED,DEPT PATHOL,DETROIT,MI 48201

来源：

TUMOR BIOLOGY | 1991年 / 12卷 / 03期

关键词：

TRANSFORMING GROWTH FACTOR-BETA; ENDOTHELIAL CELL; ROUS SARCOMA VIRUS;

D O I：

10.1159/000217702

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This study describes the preliminary characterization of a Rous sarcoma virus (RSV)-transformed rat cerebral microvascular endothelial cell (RCE-T1)-derived growth factor with biological properties similar to transforming growth factor-beta (TGF-beta). A significant portion of this RCE-T1-derived TGF-beta-like growth factor was secreted in an active form and its secretion was elevated 2- to 3-fold in late passage cultures comprised of rapidly growing, less differentiated cells exhibiting reduced sensitivity to the growth-inhibitory effects of exogenous TGF-beta-1. These data suggest that the RCE-T1 cell line may be a useful system in which to study the role of autocrine TGF-beta-production in normal and aberrant endothelial cell growth.

引用

页码：171 / 183

页数：13

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