PRODUCTION OF A TRANSFORMING GROWTH FACTOR-BETA-LIKE GROWTH-FACTOR BY RSV-TRANSFORMED RAT CEREBRAL MICROVASCULAR ENDOTHELIAL-CELLS

被引：8
|
作者：
MOORADIAN, DL [1 ]
DIGLIO, CA [1 ]
机构：
[1] WAYNE STATE UNIV,SCH MED,DEPT PATHOL,DETROIT,MI 48201
来源：
TUMOR BIOLOGY | 1991年 / 12卷 / 03期
关键词：
TRANSFORMING GROWTH FACTOR-BETA; ENDOTHELIAL CELL; ROUS SARCOMA VIRUS;
D O I：
10.1159/000217702
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
This study describes the preliminary characterization of a Rous sarcoma virus (RSV)-transformed rat cerebral microvascular endothelial cell (RCE-T1)-derived growth factor with biological properties similar to transforming growth factor-beta (TGF-beta). A significant portion of this RCE-T1-derived TGF-beta-like growth factor was secreted in an active form and its secretion was elevated 2- to 3-fold in late passage cultures comprised of rapidly growing, less differentiated cells exhibiting reduced sensitivity to the growth-inhibitory effects of exogenous TGF-beta-1. These data suggest that the RCE-T1 cell line may be a useful system in which to study the role of autocrine TGF-beta-production in normal and aberrant endothelial cell growth.
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页码：171 / 183
页数：13
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