ANTI-SELECTIVE AND DIASTEREOFACIALLY SELECTIVE ALDOL REACTIONS WITH (R)-2-SILOXY-1,2,2-TRIPHENYLETHYL PROPIONATE

被引：29

作者：

BRAUN, M

SACHA, H

机构：

[1] Institut Für Organische, Makromolekulare Chemie, Universität Düsseldorf, W-4000

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1991年 / 30卷 / 10期

关键词：

D O I：

10.1002/anie.199113181

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The zirconium enolate of the (R)-propionate 1 attacks aldehydes preferentially at the Si side to afford anti-configurated adducts. The chiral auxiliary triphenylglycol, which is the precursor to the ester 1, is easily accessible in both enantiomeric forms. Thus, access to the carboxylic acids 2 and diols 3 is provided with enantiomeric excesses of > 94%.

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页码：1318 / 1320

页数：3

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