METABOLIC PATHWAYS OF SODIUM BISULFITE INJECTED INTRAVENOUSLY IN RABBITS

被引：3
作者：
TOGAWA, T
TANABE, S
KATO, M
KOSHIISHI, I
TOIDA, T
IMANARI, T
机构：
[1] CHIBA UNIV,FAC PHARMACEUT SCI,YAYOI,CHIBA 260,JAPAN
[2] MEIJI COLL PHARM,DEPT ANALYT CHEM,TANASHI 188,JAPAN
来源：
JOURNAL OF PHARMACOBIO-DYNAMICS | 1990年 / 13卷 / 02期
关键词：
plasma; rabbit; red blood cell; S-sulfoalbumin; S-sulfocysteine; S-sulfoglutathione; sulfate; sulfite; thiosulfate; urine;
D O I：
10.1248/bpb1978.13.83
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The metabolites of sodium bisulfite in rabbits through intravenous injection were examined according to the high performance liquid chromatography method for determination of sulfur-containing substances. Most of the administered sulfite was oxidized to sulfate, and a small part was converted to thiosulfate, S- sulfoalbumin, S- sulfoglutathione and S- sulfocysteine. Furthermore, it was found that S- sulfocysteine administered intravenously to a rabbit was partially changed to inorganic sulfate and thiosulfate. These metabolites produced from sulfite in rabbits indicated the presence of the many and complicated metabolic pathways of sulfite in vivo. © 1990, The Pharmaceutical Society of Japan. All rights reserved.
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页码：83 / 89
页数：7
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