TIME-RESOLVED X-RAY-DIFFRACTION STUDIES OF THE B-REVERSIBLE-D STRUCTURAL TRANSITION IN THE DNA DOUBLE HELIX

被引：38

作者：

MAHENDRASINGAM, A ^{[1
]}

FORSYTH, VT ^{[1
]}

HUSSAIN, R ^{[1
]}

GREENALL, RJ ^{[1
]}

PIGRAM, WJ ^{[1
]}

FULLER, W ^{[1
]}

机构：

[1] SERC,DARESBURY LAB,WARRINGTON WA4 4AD,CHESHIRE,ENGLAND

来源：

SCIENCE | 1986年 / 233卷 / 4760期

关键词：

BIOCHEMISTRY - DNA Sequences - POLYMERS - Synthesis - X-RAY ANALYSIS - X-RAYS - Diffraction;

D O I：

10.1126/science.3726529

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Because of the relation between topology and function, there has been much interest in the structural transitions of the various conformations of DNA polymers. The x-ray fiber diffraction analysis system at the Daresbury Synchrotron Radiation Source was used to study the reversible transition between the B and D forms of the synthetic DNA poly left bracket d(A-T) right bracket multiplied by (times) poly left bracket d(A-T) right bracket . The gradual progression of conformations between these two forms indicates that the DNA double helix does not undergo a change of handedness during this transition.

引用

页码：195 / 197

页数：3