TIME-RESOLVED X-RAY-DIFFRACTION STUDIES OF THE B-REVERSIBLE-D STRUCTURAL TRANSITION IN THE DNA DOUBLE HELIX

被引：38
|
作者：
MAHENDRASINGAM, A [1 ]
FORSYTH, VT [1 ]
HUSSAIN, R [1 ]
GREENALL, RJ [1 ]
PIGRAM, WJ [1 ]
FULLER, W [1 ]
机构：
[1] SERC,DARESBURY LAB,WARRINGTON WA4 4AD,CHESHIRE,ENGLAND
来源：
SCIENCE | 1986年 / 233卷 / 4760期
关键词：
BIOCHEMISTRY - DNA Sequences - POLYMERS - Synthesis - X-RAY ANALYSIS - X-RAYS - Diffraction;
D O I：
10.1126/science.3726529
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Because of the relation between topology and function, there has been much interest in the structural transitions of the various conformations of DNA polymers. The x-ray fiber diffraction analysis system at the Daresbury Synchrotron Radiation Source was used to study the reversible transition between the B and D forms of the synthetic DNA poly left bracket d(A-T) right bracket multiplied by (times) poly left bracket d(A-T) right bracket . The gradual progression of conformations between these two forms indicates that the DNA double helix does not undergo a change of handedness during this transition.
引用
收藏
页码：195 / 197
页数：3
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