A ROLE FOR THE CYTOPLASMIC TAIL OF THE BETA-CHAIN OF CD8 IN THYMIC SELECTION

被引：65
作者：
ITANO, A
CADO, D
CHAN, FKM
ROBEY, E
机构：
[1] Department of Molecular, Cell Biology University of California, Berkeley, Berkeley
来源：
IMMUNITY | 1994年 / 1卷 / 04期
关键词：
D O I：
10.1016/1074-7613(94)90080-9
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The CD8 coreceptor plays a critical role in the recognition of foreign antigens by mature T cells and in the development of class I-restricted T cells. CD8 can be expressed on the surface of T cells as either a heterodimer composed of an alpha and beta chain, or as a homodimer composed of two alpha chains. In this report, we show that a CD8 beta transgene that lacks a cytoplasmic domain can suppress expression of wild-type endogenous CD8 beta and act as a dominant negative mutation. We show that this dominant negative CD8 beta transgene interferes with the development of mature CD8 T cells to different extents depending on the individual class I-restricted TCR. These data suggest CD8 beta plays a role in thymic development, and that different class I-restricted TCRs differ in their dependence on the cytoplasmic tail of CD8 beta.
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页码：287 / 290
页数：4
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