NO STRUCTURAL MUTATION IN THE DOPAMINE-D2 RECEPTOR GENE IN ALCOHOLISM OR SCHIZOPHRENIA - ANALYSIS USING DENATURING GRADIENT GEL-ELECTROPHORESIS

被引:200
作者
GEJMAN, PV
RAM, A
GELERNTER, J
FRIEDMAN, E
CAO, QH
PICKAR, D
BLUM, K
NOBLE, EP
KRANZLER, HR
OMALLEY, S
HAMER, DH
WHITSITT, F
RAO, P
DELISI, LE
VIRKKUNEN, M
LINNOILA, M
GOLDMAN, D
GERSHON, ES
机构
[1] NIMH, EXPTL THERAPEUT BRANCH, BETHESDA, MD 20892 USA
[2] YALE UNIV, MED CTR, DEPT PSYCHIAT, NEW HAVEN, CT 06520 USA
[3] VET AFFAIRS MED CTR, W HAVEN, CT USA
[4] KAROLINSKA HOSP, DEPT CLIN GENET, S-10401 STOCKHOLM 60, SWEDEN
[5] UNIV TEXAS, HLTH SCI CTR, DEPT PHARMACOL, SAN ANTONIO, TX 78284 USA
[6] UNIV CALIF LOS ANGELES, NEUROPSYCHIAT INST & BRAIN RES, ALCOHOL RES CTR, LOS ANGELES, CA USA
[7] UNIV CONNECTICUT, CTR HLTH, ALCOHOL RES CTR, FARMINGTON, CT 06032 USA
[8] NCI, BIOCHEM LAB, BETHESDA, MD 20892 USA
[9] SUNY STONY BROOK, HLTH SCI CTR, DEPT PSYCHIAT & BEHAV SCI, STONY BROOK, NY 11794 USA
[10] UNIV HELSINKI, DEPT PSYCHIAT, SF-00100 HELSINKI 10, FINLAND
[11] NIAAA, DIV INTRAMURAL CLIN & BIOL RES, CLIN STUDIES LAB, BETHESDA, MD USA
[12] NIAAA, NEUROGENET LAB, BETHESDA, MD 20892 USA
来源
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION | 1994年 / 271卷 / 03期
关键词
D O I
10.1001/jama.271.3.204
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective.-To examine the dopamine D2 receptor (DRD2) gene coding sequences for abnormalities associated with schizophrenia or alcoholism and thereby help to resolve the controversy surrounding the reported association of alcoholism with a restriction fragment length polymorphism located close to the DRD2 gene. Design.-Mutational analysis of complete DRD2 gene coding sequences by denaturing gradient gel electrophoresis followed by direct nucleotide sequencing of detected variants. Setting.-Patients and controls from clinical and epidemiologic collections in the United States and Europe. Patients.-A total of 253 unrelated individuals, including 106 patients with schizophrenia, 113 with alcoholism, and 34 controls. For alcoholism we included patients from previously published series in which an association of illness with allele A1 was reported (Taq I site 3' to the DRD2 gene) and from other published series in which nonconfirmations of this association were reported. Nearly all persons examined were white. Main Outcome Measures.-Frequency of nonsilent variations in DRD2 gene DNA sequences in the different diagnostic groups. Results.-We found three infrequent DNA variants that predict altered amino acid sequence of the receptor. None of these is associated with either alcoholism or schizophrenia. Conclusion.-No structural coding abnormalities in the DRD2 gene are present in alcoholism or schizophrenia.
引用
收藏
页码:204 / 208
页数:5
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