THE SYNTHESIS OF (+)-FLESINOXAN AND (-)-FLESINOXAN - APPLICATION OF ENZYMATIC RESOLUTION METHODOLOGY

被引：24

作者：

ENNIS, MD

GHAZAL, NB

机构：

[1] Medicinal Chemistry Research The Upjohn Company, Kalamazoo

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 42期

关键词：

D O I：

10.1016/S0040-4039(00)60954-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of (+/-)-flesinoxan was carried out in seven steps starting from catechol. An enzymatic resolution was utilized to prepare each enantiomer. Based upon the known preferences of the enzyme system used, we have assigned the (R)-configuration to the (+)-flesinoxan isomer.

引用

页码：6287 / 6290

页数：4

共 8 条

[1] ANHYDRIDES AS ACYLATING AGENTS IN LIPASE-CATALYZED STEREOSELECTIVE ESTERIFICATION OF RACEMIC ALCOHOLS [J].