Extramedullary blast crisis as initial presentation in chronic myeloid leukemia with the e1a2 BCR-ABL1 transcript: A case report

被引：2

作者：

Ai, Di ^{[1
,2
]}

Liu, Wei ^{[1
,3
]}

Lu, Gary ^{[1
]}

Patel, Keyur Pravinchandra ^{[1
]}

Chen, Zi ^{[1
,4
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Hematopathol, Houston, TX 77030 USA

[2] Scott & White Mem Hosp & Clin, Texas A&M Hlth Sci Ctr, Dept Pathol, Temple, TX 76508 USA

[3] Soochow Univ, Affiliated Hosp 1, Dept Pathol, Suzhou 215006, Jiangsu, Peoples R China

[4] Fudan Univ, Huashan Hosp, Dept Hematol, 12 Urumqi Middle Rd, Shanghai 200040, Peoples R China

来源：

MOLECULAR AND CLINICAL ONCOLOGY | 2015年 / 3卷 / 06期

关键词：

bone marrow transplant; chronic myeloid leukemia; e1a2; transcript; extramedullary blast crisis; targeted therapy;

D O I：

10.3892/mco.2015.641

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A 23-year-old woman presented with enlarged right inguinal lymph nodes. The pathological examination of the nodes revealed infiltration by myeloid sarcoma. A bone marrow smear and biopsy revealed cytogenetic abnormalities, with 46, XX,t(9;22) and chronic myeloid leukemia (CML) was diagnosed. The e1a2 BCR-ABL1 fusion transcript was detected. The patient received imatinib-based combined chemotherapy, allogeneic hematopoietic stem cell transplantation, donor lymphocyte infusions and dasatinib treatment. The patient achieved complete response and has remained leukemia-free for >48 months. To the best of our knowledge, this is the first case report of CML with the e1a2 BCR-ABL1 transcript, with extramedullary blast crisis as the initial presentation. The aim of the present study was to discuss this special case with reference to the literature.

引用

页码：1319 / 1322

页数：4

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