CUTOFF EFFECT OF N-ALKANOLS IN AN EXCITABLE MODEL MEMBRANE COMPOSED OF DIOLEYL PHOSPHATE

被引：3

作者：

IIYAMA, S

TOKO, K

MURATA, T

ICHINOSE, H

SUEZAKI, Y

KAMAYA, H

UEDA, I

YAMAFUJI, K

机构：

[1] KYUSHU UNIV 36,FAC ENGN,DEPT ELECTR,FUKUOKA 812,JAPAN

[2] UNIV UTAH,SCH MED,DEPT ANESTHESIA,SALT LAKE CITY,UT 84132

[3] SAGA MED SCH,PHYS LAB,SAGA 84001,JAPAN

来源：

BIOPHYSICAL CHEMISTRY | 1992年 / 45卷 / 02期

关键词：

ANESTHETICS; N-ALKANOLS; MEMBRANE POTENTIAL; MEMBRANE RESISTANCE; CUTOFF EFFECT; ELECTRICAL OSCILLATION;

D O I：

10.1016/0301-4622(92)87001-Y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of n-alkanols from ethanol to tridecanol interacted with a negatively charged lipid membrane composed of dioleyl phosphate, which exhibited a self-sustained oscillation of the membrane potential. A cutoff effect was observed in the electrical characteristics of the membrane; e.g., alkanols with carbon atoms less than 11 decreased the membrane resistance and alkanols with more than 12 carbon atoms increased it. n-Alkanols usually depressed the oscillation of the membrane potentials as it has been observed in biological systems. Electrochemical theory provided a quantitative explanation of the observed electrical charactersitics.

引用

页码：91 / 100

页数：10

共 43 条

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