CUTOFF EFFECT OF N-ALKANOLS IN AN EXCITABLE MODEL MEMBRANE COMPOSED OF DIOLEYL PHOSPHATE

被引：3
|
作者：
IIYAMA, S
TOKO, K
MURATA, T
ICHINOSE, H
SUEZAKI, Y
KAMAYA, H
UEDA, I
YAMAFUJI, K
机构：
[1] KYUSHU UNIV 36,FAC ENGN,DEPT ELECTR,FUKUOKA 812,JAPAN
[2] UNIV UTAH,SCH MED,DEPT ANESTHESIA,SALT LAKE CITY,UT 84132
[3] SAGA MED SCH,PHYS LAB,SAGA 84001,JAPAN
来源：
BIOPHYSICAL CHEMISTRY | 1992年 / 45卷 / 02期
关键词：
ANESTHETICS; N-ALKANOLS; MEMBRANE POTENTIAL; MEMBRANE RESISTANCE; CUTOFF EFFECT; ELECTRICAL OSCILLATION;
D O I：
10.1016/0301-4622(92)87001-Y
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A series of n-alkanols from ethanol to tridecanol interacted with a negatively charged lipid membrane composed of dioleyl phosphate, which exhibited a self-sustained oscillation of the membrane potential. A cutoff effect was observed in the electrical characteristics of the membrane; e.g., alkanols with carbon atoms less than 11 decreased the membrane resistance and alkanols with more than 12 carbon atoms increased it. n-Alkanols usually depressed the oscillation of the membrane potentials as it has been observed in biological systems. Electrochemical theory provided a quantitative explanation of the observed electrical charactersitics.
引用
收藏
页码：91 / 100
页数：10
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