CRYSTALLOGRAPHIC INVESTIGATIONS OF THE TRYPTOPHAN-DERIVED COFACTOR IN THE QUINOPROTEIN METHYLAMINE DEHYDROGENASE

被引：76
作者：
CHEN, LY
MATHEWS, FS
DAVIDSON, VL
HUIZINGA, EG
VELLIEUX, FMD
DUINE, JA
HOL, WGJ
机构：
[1] WASHINGTON UNIV,SCH MED,DEPT CELL BIOL & PHYSIOL,ST LOUIS,MO 63110
[2] TECH UNIV DELFT,MICROBIOL & ENZYMOL LAB,2600 GB DELFT,NETHERLANDS
[3] UNIV MISSISSIPPI,MED CTR,DEPT BIOCHEM,JACKSON,MS 39216
[4] STATE UNIV GRONINGEN,BIOSON RES INST,9747 AG GRONINGEN,NETHERLANDS
来源：
FEBS LETTERS | 1991年 / 287卷 / 1-2期
关键词：
METHYLAMINE DEHYDROGENASE; QUINOPROTEIN; REDOX COFACTOR; TRYPTOPHAN TRYPTOPHYLQUINONE; PYRROLOQUINOLINE QUINONE; AMINO ACID-DERIVED COFACTOR;
D O I：
10.1016/0014-5793(91)80041-Z
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A model of tryptophan tryptophylquinone (TTQ), recently proposed by McIntire et al. (Science (1991) 252, 817-824) to be the prosthetic group of the quinoprotein methylamine dehydrogenase, has been compared with electron density maps of this dehydrogenase form Thiobacillus versutus and Paracoccus denitrificans. The comparison shows that the TTQ model can be neatly accommodated, providing strong supportive evidence that TTQ is indeed the cofactor for this group of quinoproteins.
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页码：163 / 166
页数：4
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