INTERACTIVE COMPUTER SYSTEM FOR THE ANALYSIS OF CELL LINEAGES

被引：6

作者：

BELL, E ^{[1
]}

LEVINSTONE, D ^{[1
]}

SHER, S ^{[1
]}

MAREK, L ^{[1
]}

MERRILL, C ^{[1
]}

YOUNG, I ^{[1
]}

EDEN, M ^{[1
]}

机构：

[1] MIT,DEPT ELECT ENGN & COMP SCI,CAMBRIDGE,MA 02139

来源：

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY | 1979年 / 27卷 / 01期

关键词：

D O I：

10.1177/27.1.374610

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The authors have developed an interactive computer system for analysing cell lineage data. It can be utilized in studies of cell motility, cell division, cell differentiation, and cell aging. It has enabled us to document the heterogeneity of human foreskin fibroblasts in culture and to propose that loss of proliferative potential may mean that cells enter a state of differentiation which makes them unable to respond to mitotic stimulation. Our method, which enables us to apply immunological and cytochemical probes after recording the history of a cell lineage, should allow us to define precisely features which uniquely distinguish cycling from noncycling cells on an individual cell basis.

引用

页码：458 / 462

页数：5

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