INHIBITORY EFFECT OF GOSSYPOL ON HUMAN CHORIONIC-GONADOTROPIN (HCG)-INDUCED PROGESTERONE SECRETION IN CULTURED BOVINE LUTEAL CELLS

被引：18

作者：

GU, Y ^{[1
]}

CHANG, CJG ^{[1
]}

RIKIHISA, Y ^{[1
]}

LIN, YC ^{[1
]}

机构：

[1] OHIO STATE UNIV,COLL VET MED,DEPT VET PATHOBIOL,COLUMBUS,OH 43210

来源：

LIFE SCIENCES | 1990年 / 47卷 / 05期

关键词：

D O I：

10.1016/0024-3205(90)90298-6

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Inhibitory effects of gossypol on the female reproductive system have been recently reported. This study investigated a possible site of gossypol action on progesterone synthesis. Bovine luteal cells were cultured with hCG and forskolin in the presence or absence of gossypol. At 10 μg/ml, gossypol significantly inhibited hCG- and forskolin-stimulated progesterone secretion and intracellular cAMP formation; at 20 μg/ml, gossypol completely abolished the stimulative effect of hCG and forskolin. The results suggest that adenylate cyclase may be a site of gossypol action on steroidogenesis of bovine luteal cells. © 1990.

引用

页码：407 / 414

页数：8

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