ENHANCED VASOCONSTRICTOR EFFECT OF ENDOTHELIN IN CEREBRAL-ARTERIES FROM RATS WITH SUBARACHNOID HEMORRHAGE

被引：54

作者：

ALAFACI, C

JANSEN, I

ARBAB, MAR

SHIOKAWA, Y

SVENDGAARD, NA

EDVINSSON, L

机构：

[1] UNIV LUND HOSP,DEPT INTERNAL MED,S-22185 LUND,SWEDEN

[2] UNIV LUND HOSP,DEPT EXPTL RES,S-22185 LUND,SWEDEN

[3] UNIV LUND HOSP,DEPT NEUROSURG,S-22185 LUND,SWEDEN

来源：

ACTA PHYSIOLOGICA SCANDINAVICA | 1990年 / 138卷 / 03期

关键词：

Cerebral artery; Endothelin; Rat; Subarachnoid haemorrhage;

D O I：

10.1111/j.1748-1716.1990.tb08852.x

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The contractile response to endothelin has been examined in cerebral arteries from rats subjected to a prior subarachnoid haemorrhage (SAH) and compared with saline-injected controls. Endothelin elicited concentration-dependent contractions of rat basilar artery segments. The endothelin-induced contractions were much stronger in the SAH compared to control animals, which suggests a role in the pathophysiology of cerebral vasospasm.

引用

页码：317 / 319

页数：3

共 6 条

[1] SUBARACHNOID HEMORRHAGE IN THE RAT - ANGIOGRAPHY AND FLUORESCENCE MICROSCOPY OF THE MAJOR CEREBRAL-ARTERIES [J].