STRUCTURES OF 3 NEW CYCLIC HEPTAPEPTIDE HEPATOTOXINS PRODUCED BY THE CYANOBACTERIUM (BLUE-GREEN-ALGA) NOSTOC SP STRAIN 152

被引：131

作者：

NAMIKOSHI, M

RINEHART, KL

SAKAI, R

SIVONEN, K

CARMICHAEL, WW

机构：

[1] UNIV ILLINOIS,ROGER ADAMS LAB,URBANA,IL 61801

[2] UNIV HELSINKI,DEPT MICROBIOL,SF-00710 HELSINKI,FINLAND

[3] WRIGHT STATE UNIV,DEPT BIOL SCI,DAYTON,OH 45435

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1990年 / 55卷 / 25期

关键词：

D O I：

10.1021/jo00312a019

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three new hepatotoxic cyclic heptapeptides in the microcystin class were isolated from the cyanobacterium (blue-green alga) Nostoc sp. strain 152 and assigned structures based on their high-resolution FABMS, FABMS/MS, 1H and 13C NMR spectra, amino acid analysis, and GC on a chiral capillary column. All three toxins (1–3) have 9-acetoxy-3-amino-2,6,8-trimethyl-10-phenyl-4,6-decadienoic acid as an unusual structural component (Scheme I) instead of the corresponding 9-methoxyl derivative (Adda) found in the microcystins. © 1990, American Chemical Society. All rights reserved.

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页码：6135 / 6139

页数：5

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