Defibrotide in the treatment of hepatic veno-occlusive disease

被引：6

作者：

Fulgenzi, Alessandro ^{[1
]}

Ferrero, Maria Elena ^{[1
]}

机构：

[1] Univ Milan, Dept Biomed Sci Hlth, Via Mangiagalli 31, I-20133 Milan, Italy

来源：

HEPATIC MEDICINE-EVIDENCE AND RESEARCH | 2016年 / 8卷

关键词：

hepatic veno-occlusive disease; hematopoietic stem-cell transplantation; defibrotide;

D O I：

10.2147/HMER.S79243

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Hepatic veno-occlusive disease (VOD), also known as sinusoidal obstruction syndrome (SOS), represents the most frequent complication in patients in early phase following hematopoietic stem-cell transplantation (HSCT). In its severe form, VOD/SOS can be associated with multiorgan failure and with a mortality rate >80% by day +100. Defibrotide (DF) (a mixture of 90% single-stranded phosphodiester oligonucleotides and 10% double-stranded phosphodiester oligonucleotides derived from controlled depolarization of porcine intestinal mucosal DNA) has been proposed for the treatment of SOS due to its ability to restore thrombo-fibrinolytic balance and protect endothelial cells. The present review highlights why the mechanisms of action of DF allow its successful use in the prevention and treatment of SOS following HSCT.

引用

页码：105 / 113

页数：9

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