EXPRESSION OF THE ALPHA(2)-MACROGLOBULIN RECEPTOR ON HUMAN NEOPLASTIC FIBROBLASTOID CELLS

被引：0

作者：

GROFOVA, M ^{[1
]}

MATOSKA, J ^{[1
]}

BIES, J ^{[1
]}

VAHERI, A ^{[1
]}

BIZIK, J ^{[1
]}

机构：

[1] HELSINKI UNIV,DEPT VIROL,HELSINKI,FINLAND

来源：

NEOPLASMA | 1995年 / 42卷 / 03期

关键词：

ALPHA(2)-MACROGLOBULIN; RECEPTOR; NEOPLASTIC FIBROBLASTS;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The alpha(2)-macroglobulin membrane-associated receptor (alpha(2)MR) has been previously detected on hepatocytes, fibroblasts, macrophages, syncytiotrophoblasts and recently on human malignant blood cells of myelomonocytic leukemia. In cells growing in vitro from human germ cell tumors alpha(2)MR mRNA was detected by Northern blotting. Endocytosis of alpha(2)M from culture medium was detected in these cells by indirect immunofluorescence. In cell extracts alpha(2)MR and its degradation products were detected by immunoblotting. The cells expressing alpha(2)MR and internalizing alpha(2)M were identified as fibroblasts both by their morphology and expression of vimentin intermediate filaments. The role and function of alpha(2)MR receptor in the analyzed neoplastic cells of teratomatous origin is discussed.

引用

页码：97 / 103

页数：7