INHIBITION OF MITOGEN-STIMULATED PROLIFERATION OF HUMAN-LYMPHOCYTES IN-VITRO BY SYNTHETIC PEPTIDE-FRAGMENTS OF ALPHA-2 INTERFERON

被引：1
作者：
DANILKOVICH, AV
FREZE, KV
TARGONI, OS
KARULIN, AY
SHEVALE, AF
GUSEV, MV
SUKHIKH, GT
机构：
[1] AN BAKH BIOCHEM INST,IMMUNOBIOCHEM LAB,MOSCOW 117071,RUSSIA
[2] MM SHEMYAKIN INST BIOORGAN CHEM,NEUROPEPTIDE RECEPT LAB,MOSCOW,RUSSIA
[3] RUSSIAN MINIST HLTH,RUSSIAN RES CTR PERINATOL OBSTET & GYNECOL,CLIN IMMUNOL LAB,MOSCOW,RUSSIA
[4] YA OVCHINNIKOV BIOORGAN CHEM INST,MOSCOW,RUSSIA
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 1994年 / 117卷 / 01期
关键词：
INTERFERON; PEPTIDES; LYMPHOCYTES; PROLIFERATION; INHIBITION;
D O I：
10.1007/BF02444086
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Human alpha-2 interferon and peptides representing parts of the amino-acid sequence 124-138 of the IF molecule inhibit the proliferative response of peripheral blood lymphocytes from healthy donors in vitro induced by ConA. It is shown that neither interferon alpha-2 nor biologically active peptides change the level of interleukin-2 ConA-induced production by human blood mononuclears.
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收藏
页码：75 / 78
页数：4
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