CHANGES IN BRAIN CAPILLARY DIAMETER DURING HYPOCAPNIA AND HYPERCAPNIA

被引：79

作者：

DUELLI, R ^{[1
]}

KUSCHINSKY, W ^{[1
]}

机构：

[1] UNIV HEIDELBERG,INST PHYSIOL,DEPT PHYSIOL,NEUENHEIMER FELD 326,D-69120 HEIDELBERG,GERMANY

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 1993年 / 13卷 / 06期

关键词：

BRAIN CAPILLARIES; MICROCIRCULATION; HYPOCAPNIA; HYPERCAPNIA; PERFUSION FIXATION; CAPILLARY SURFACE AREA; CAPILLARY COMPLIANCE;

D O I：

10.1038/jcbfm.1993.129

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Since changes in the surface area of capillaries may be relevant to capillary exchange, the distensibility of brain capillaries was investigated. Brain capillary diameters were measured after perfusion fixation of brain tissue at a constant perfusion pressure during hypo- or hypercapnia. Sections were embedded, stained, and analyzed by light microscopy. The results showed significant differences in mean capillary diameter between the hypocapnic and the hypercapnic group. In the eight brain structures analyzed, capillary diameters were always larger in the hypercapnic group. Mean capillary diameter was 4.93 +/- 0.29 mum in the hypocapnic group and 5.91 +/-0.10 mum in the hypercapnic group (means +/- SD). We conclude that brain capillaries exhibit a moderate degree of distensibility. Variations in the precapillary pressure of microvessels may therefore influence both capillary flow and capillary surface area.

引用

页码：1025 / 1028

页数：4

共 15 条

[1] THE EFFECT OF CARBON-DIOXIDE ON THE DIAMETER OF BRAIN CAPILLARIES [J].

ATKINSON, JLD ;

ANDERSON, RE ;

SUNDT, TM .

BRAIN RESEARCH, 1990, 517 (1-2) :333-340

[2]

BAEZ S, 1960, FLOW PROPERTIES BLOO, P122

[3] SIMULTANEOUS MEASUREMENT OF CAPILLARY DISTENSIBILITY AND HYDRAULIC CONDUCTANCE [J].

BALDWIN, AL ;

GORE, RW .

MICROVASCULAR RESEARCH, 1989, 38 (01) :1-22

[4] MICRO-CIRCULATION OF LEFT ATRIAL MUSCLE, CEREBRAL-CORTEX AND MESENTERY OF THE CAT - A COMPARATIVE-ANALYSIS [J].

CHANG, B ;

YAMAKAWA, T ;

NUCCIO, J ;

PACE, R ;

BING, RJ .

CIRCULATION RESEARCH, 1982, 50 (02) :240-249

[5] MICROVASCULAR CONTROL OF CAPILLARY-PRESSURE DURING INCREASES IN LOCAL ARTERIAL AND VENOUS-PRESSURE [J].

DAVIS, MJ .

AMERICAN JOURNAL OF PHYSIOLOGY, 1988, 254 (04) :H772-H784

[6] ELASTIC ENVIRONMENT OF CAPILLARY BED [J].

FUNG, YC ;

ZWEIFACH, BW ;

INTAGLIETTA, M .

CIRCULATION RESEARCH, 1966, 19 (02) :441-+

[7] LACK OF CAPILLARY RECRUITMENT IN THE BRAINS OF AWAKE RATS DURING HYPERCAPNIA [J].

GOBEL, U ;

KLEIN, B ;

SCHROCK, H ;

KUSCHINSKY, W .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1989, 9 (04) :491-499

[8] TOPOGRAPHY OF CAPILLARY DENSITY, GLUCOSE-METABOLISM, AND MICROVASCULAR FUNCTION WITHIN THE RAT INFERIOR COLLICULUS [J].

GROSS, PM ;

SPOSITO, NM ;

PETTERSEN, SE ;

PANTON, DG ;

FENSTERMACHER, JD .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1987, 7 (02) :154-160

[9]

KUSCHINSKY W, 1992, CEREBROVAS BRAIN MET, V4, P261

[10] CAPILLARY SIZE AND DENSITY IN CEREBRAL-CORTEX OF RATS WITH A PORTACAVAL ANASTOMOSIS [J].

LAURSEN, H ;

DIEMER, NH .

ACTA NEUROPATHOLOGICA, 1977, 40 (02) :117-122

← 1 2 →