EFFECTS OF GRINDING AND COMPRESSION ON CRYSTAL-STRUCTURE OF ANHYDROUS CAFFEINE

被引：81
|
作者：
PIRTTIMAKI, J
LAINE, E
KETOLAINEN, J
PARONEN, P
机构：
[1] UNIV TURKU,DEPT PHYS,IND PHYS LAB,SF-20500 TURKU 50,FINLAND
[2] UNIV KUOPIO,DEPT PHARMACEUT TECHNOL,SF-70211 KUOPIO,FINLAND
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1993年 / 95卷 / 1-3期
关键词：
CAFFEINE; POLYMORPHISM; POLYMORPHIC BEHAVIOR; POLYMORPHIC FORM; X-RAY DIFFRACTION; TABLETTING; GRINDING; MECHANICAL TREATMENT;
D O I：
10.1016/0378-5173(93)90394-U
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The extent of the polymorphic transformation of anhydrous caffeine has been studied as a function of grinding time and compression pressure by using quantitative X-ray diffraction analysis. The measurements show that both grinding and compression induce the transformation from the metastable form I into the stable form II. The transformation can be observed even after 1 min grinding or by using a compression pressure of about 50 MPa in tableting. The degree of transformation is greater near the surface than in the middle part of the tablet.
引用
收藏
页码：93 / 99
页数：7
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