NICARBAZIN STIMULATES INTESTINAL TRANSPORT OF L-LEUCINE IN RABBIT

被引：2

作者：

SORRIBAS, V ^{[1
]}

ARRUEBO, MP ^{[1
]}

NAVARRO, H ^{[1
]}

ALCALDE, AI ^{[1
]}

机构：

[1] UNIV ZARAGOZA,FAC VET,DEPT FISIOL & FARMACOL,MIGUEL SERVET 177,E-50013 ZARAGOZA,SPAIN

来源：

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS | 1993年 / 16卷 / 01期

关键词：

D O I：

10.1111/j.1365-2885.1993.tb00286.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Nicarbazin is an anticoccidial drug used mainly in birds, but also in rabbits. Besides the anticoccidial activity, nicarbazin has shown several other effects such as inhibition of growth and feed efficiency in poultries, and stimulation of sugar intestinal absorption in rabbits. The present work has been performed in order to check whether nicarbazin also affects L-leucine intestinal absorption. The results obtained show that nicarbazin decreases L-leucine accumulation in the jejunal tissue, and increases mucosal to serosal transepithelial fluxes of this amino acid in a dose-dependent way, without modifying its diffusion across the intestinal epithelium. The drug stimulates the amino acid uptake in brush-border and basolateral membrane vesicles, thus suggesting that nicarbazin increases the absorption of L-leucine mediated by carriers.

引用

页码：32 / 37

页数：6

共 23 条

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