VIMENTIN AND DESMIN EXPRESSION IN DEGENERATING AND REGENERATING DYSTROPHIC MURINE MUSCLES

被引：0
作者：
BROCKS, L [1 ]
JAP, PHK [1 ]
RAMAEKERS, FCS [1 ]
STADHOUDERS, AM [1 ]
机构：
[1] STATE UNIV LIMBURG,DEPT MOLEC CELL BIOL,6200 MD MAASTRICHT,NETHERLANDS
来源：
VIRCHOWS ARCHIV B-CELL PATHOLOGY INCLUDING MOLECULAR PATHOLOGY | 1991年 / 61卷 / 02期
关键词：
VIMENTIN; DESMIN; CYTOSKELETON; DYSTROPHY; MOUSE; MUSCLE;
D O I：
暂无
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
The distribution of the intermediate filament proteins (IFP) desmin and vimentin was studied in gastrocnemius, plantaris and soleus muscles of the dystrophic mouse strain ReJ 129 during postnatal development. Special attention was paid to the overall morphological changes in the distribution of these cytoskeletal constituents in degenerating and regenerating muscle fibres. In contrast to their normal counterparts, the dystrophic mice (ReJ 129 dy/dy) appeared to develop four types of distinct muscle fibres with immunohistochemically detectable aberrant IFP patterns. The distribution of desmin IFP differed in the dystrophic muscle fibres as compared to the normal fibres in that juxtanuclear aggregates of IFP were frequently seen. In contrast to the recent literature we conclude that these cells are regenerated myofibres exhibiting defective nuclear migration.
引用
收藏
页码：89 / 96
页数：8
相关论文
共 30 条
  • [21] EXPRESSION PATTERN OF M-CADHERIN IN NORMAL, DENERVATED, AND REGENERATING MOUSE MUSCLES
    IRINTCHEV, A
    ZESCHNIGK, M
    STARZINSKIPOWITZ, A
    WERNIG, A
    DEVELOPMENTAL DYNAMICS, 1994, 199 (04) : 326 - 337
  • [22] EXPRESSION OF A DEVELOPMENTALLY REGULATED CROSS-LINKING INTERMEDIATE FILAMENT-ASSOCIATED PROTEIN (IFAPA-400) DURING THE REPLACEMENT OF VIMENTIN FOR DESMIN IN MUSCLE-CELL DIFFERENTIATION
    COSSETTE, LJ
    VINCENT, M
    JOURNAL OF CELL SCIENCE, 1991, 98 : 251 - 260
  • [23] Characterization of mesoangioblast cell fate and improved promyogenic potential of a satellite cell-like subpopulation upon transplantation in dystrophic murine muscles
    Mavoungou, Lionel O.
    Neuenschwander, Samuel
    Pham, Uyen
    Iyer, Pavithra S.
    Mermod, Nicolas
    STEM CELL RESEARCH, 2019, 41
  • [24] Octa-guanidine Morpholino Restores Dystrophin Expression in Cardiac and Skeletal Muscles and Ameliorates Pathology in Dystrophic mdx Mice
    Wu, Bo
    Li, Yongfu
    Morcos, Paul A.
    Doran, Timothy J.
    Lu, Peijuan
    Lu, Qi Long
    MOLECULAR THERAPY, 2009, 17 (05) : 864 - 871
  • [25] Increase of CGRP Expression in Motor Endplates Within Fore and Hind Limb Muscles of the Degenerating Muscle Mouse (Scn8admu)
    Tadasu Sato
    Yoshinaka Shimizu
    Mitsuhiro Kano
    Toshihiko Suzuki
    Hiroyasu Kanetaka
    Leona W. G. Chu
    Patrice D. Côté
    Hidetoshi Shimauchi
    Hiroyuki Ichikawa
    Cellular and Molecular Neurobiology, 2011, 31 : 155 - 161
  • [26] The physiological effects of IGF-1 (class 1:Ea transgene) over-expression on exercise-induced damage and adaptation in dystrophic muscles of mdx mice
    James A. Ridgley
    Gavin J. Pinniger
    Peter W. Hamer
    Miranda D. Grounds
    Pflügers Archiv - European Journal of Physiology, 2009, 457 : 1121 - 1132
  • [27] The physiological effects of IGF-1 (class 1:Ea transgene) over-expression on exercise-induced damage and adaptation in dystrophic muscles of mdx mice
    Ridgley, James A.
    Pinniger, Gavin J.
    Hamer, Peter W.
    Grounds, Miranda D.
    PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2009, 457 (05): : 1121 - 1132
  • [28] Myogenic differentiation factor 1 and myogenin expression not elevated in regenerated masticatory muscles of dystrophic (mdx) mice Unveränderte Expression von Myogenic Differentiation Factor 1 und Myogenin in der regenerierten Kaumuskulatur der Mdx-Maus
    A. Spassov
    T. Gredes
    C. Lehmann
    T. Gedrange
    S. Lucke
    D. Pavlovic
    C. Kunert-Keil
    Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie, 2011, 72 : 469 - 475
  • [29] Olfactory receptor Olfr78 (prostate-specific G protein-coupled receptor PSGR) expression in arterioles supplying skeletal and cardiac muscles and in arterioles feeding some murine organs
    Petra Mermer
    Jörg Strotmann
    Wolfgang Kummer
    Renate Paddenberg
    Histochemistry and Cell Biology, 2021, 156 : 539 - 553
  • [30] Olfactory receptor Olfr78 (prostate-specific G protein-coupled receptor PSGR) expression in arterioles supplying skeletal and cardiac muscles and in arterioles feeding some murine organs
    Mermer, Petra
    Strotmann, Joerg
    Kummer, Wolfgang
    Paddenberg, Renate
    HISTOCHEMISTRY AND CELL BIOLOGY, 2021, 156 (06) : 539 - 553
123