PHYSICAL LINKAGE OF THE A-RAF-1, PROPERDIN, SYNAPSIN-I, AND TIMP GENES ON THE HUMAN AND MOUSE X-CHROMOSOMES

被引：32

作者：

DERRY, JMJ ^{[1
]}

BARNARD, PJ ^{[1
]}

机构：

[1] MRC,MOLEC NEUROBIOL UNIT,HILLS RD,CAMBRIDGE CB2 2QH,ENGLAND

来源：

GENOMICS | 1992年 / 12卷 / 04期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0888-7543(92)90286-2

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Genes encoding the neuron-specific phosphoprotein synapsin I (SYN1), the glycoprotein tissue inhibitor of metalloproteinases (TIMP), the proto-oncogene A-raf-1 (ARAF1), and properdin (PFC), a positive regulator of the alternative pathway of human complement, lie within a conserved synteny encompassing the proximal short arm of the human X chromosome (Xp21.1-p11) and the centromeric end of the mouse X chromosome (A1-A5). We have used a mouse interspecific cross to demonstrate genetic linkage of Syn-1, Timp, and Araf and also show physical linkage, with Timp lying only 10 kb from Araf, within an intron of the Syn-1 gene. Detailed restriction mapping shows that Timp is transcribed in the same direction as Araf but in the opposite direction to the Syn-1 gene. Analysis of the corresponding region of the human X chromosome indicates a similar arrangement and in addition shows that the properdin gene lies within 5 kb of the 5′ end of the synapsin I gene. © 1992.

引用

页码：632 / 638

页数：7

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