SERUM ELASTASE INHIBITOR DEFICIENCY AND ALPHA1-ANTITRYPSIN DEFICIENCY IN PATIENTS WITH OBSTRUCTIVE EMPHYSEMA

被引：104

作者：

TURINO, GM

SENIOR, RM

GARG, BD

KELLER, S

LEVI, MM

MANDL, I

机构：

[1] Department of Medicine, Columbia University, Presbyterian Hospital, New York, NY

[2] Division of Medicine, Walter Reed Army Institute of Research, Washington, DC

[3] Columbia University, College of Physicians and Surgeons, Francis Delafield Hospital, New York, NY

来源：

SCIENCE | 1969年 / 165卷 / 3894期

关键词：

D O I：

10.1126/science.165.3894.709

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A decreased inhibition of pancreatic elastase has been detected in the serums of six patients with α1-antitrypsin deficiency. Five have severe clinical and physiological pulmonary emphysema. This observation extends the defect of inhibition by serum to a second, biologically active proteolytic enzyme in this form of familial emphysema.

引用

页码：709 / &

共 18 条

[1]

BANGA I, 1966, STRUCTURE FUNCTION E, P58

[2] AN IMPROVED TEST FOR QUANTITATIVE DETERMINATION OF TRYPSIN, TRYPSIN-LIKE ENZYMES, AND ENZYME INHIBITORS [J].