Hepatitis C virus infection and thyroid autoimmune disorders: A model of interactions between the host and the environment

被引：29

作者：

Pastore, Francesca ^{[1
]}

Martocchia, Antonio ^{[1
]}

Stefanelli, Manuela ^{[1
]}

Prunas, Pietro ^{[1
]}

Giordano, Stefania ^{[1
]}

Toussan, Lavinia ^{[1
]}

Devito, Antonio ^{[1
]}

Falaschi, Paolo ^{[1
]}

机构：

[1] Sapienza Univ Rome, Fac Med & Psychol, S Andrea Hosp, Via Grottarossa 1035-39, I-00189 Rome, Italy

来源：

WORLD JOURNAL OF HEPATOLOGY | 2016年 / 8卷 / 02期

关键词：

Hepatitis C virus; Thyroid autoimmunity; Interferon; Antiviral agents; Self-tolerance;

D O I：

10.4254/wjh.v8.i2.83

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The hepatitis C virus (HCV) infection is an important public health problem and it is associated with hepatic and extrahepatic manifestations. Autoimmune thyroid diseases are common in HCV infected patients and the standard interferon-based treatment is associated with an increase of the immune-mediated thyroid damage. Recent evidence in the literature analyzed critical points of the mechanisms of thyroid damage, focusing on the balance between the two sides of the interaction: The environment (virus infection with potential crossreaction) and the host (susceptibility genes with consistent immune response). The spectrum of antiviral treatment for chronic HCV infection is rapidly expanding for the development of dual o triple therapy. The availability of interferon-free combined treatment with direct antiviral agents for HCV is very promising, in order to ameliorate the patient compliance and to reduce the development of thyroid autoimmunity.

引用

页码：83 / 91

页数：9

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