DO NANOPARTICLES PREPARED FROM LIPIDS SOLID AT ROOM-TEMPERATURE ALWAYS POSSESS A SOLID LIPID MATRIX

被引：117

作者：

WESTESEN, K

BUNJES, H

机构：

[1] Institute for Pharmaceutical Technology, Technical University of Braunschweig, D-38106 Braunschweig

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1995年 / 115卷 / 01期

关键词：

SOLID LIPID NANOPARTICLE; SUPERCOOLED MELT; TRIGLYCERIDE; TRILAURIN EMULSION;

D O I：

10.1016/0378-5173(94)00347-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Nanoparticles prepared by melt-emulsification from lipids solid at room temperature do not always represent suspension particles. Dispersed trilaurin forms metastable supercooled melts at room and refrigerator temperature. Such systems can be considered as o/w emulsions but not as dispersions of solid lipid nanoparticles.

引用

页码：129 / 131

页数：3

共 8 条

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[2]

MAASSEN S, 1993, P INT S CONTROLLED R, V20, P490

[3]

Muller R.H., 1993, P INT S CONTROLLED R, V20, P480

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