Introduction: Choriocarcinoma is a malignant tumor metastatic, the pathogenesis is related to the invasion of the trophoblast cells to the decidua, the beta of the human chorionic gonadotrophin (HGC) fraction is a biochemical marker sensitive. The objective is to present a mortal case of choriocarcinoma of Hospital General de Mexico OD. Clinical Case: A twenty-two-year-old female, first pregnancy, seven weeks of amenorrhea, nausea, vomit, transvaginal bleeding, disnea, molar pregnancy and uterine curettage. Examined in the emergency room, with neurological integrity, hypotension, tachypnea, tachycardia, and desaturation, cervix without changes, acidosis, azoemia, hiperuricemia, anemia, low platelets, and elevated HGC, pulmonary infiltration in four quadrants, tracheotomy, mechanic respiratory support, hemodinamic inestability, support with amines, cristaloids, coloids, blood derivates, irreversible heart arrest. The pathology result was choriocarcinoma with metastasis in lungs and right ovary. Discussion: Because of its angioinvasion, choriocarcionoma, predisposes pulmonary metastasis and to other organs, mortality increases with a late or incomplete diagnosis, with a short survival. Women must have in mind that when pregnant, they are at risk of abortion, abnormalities of placental insertion, the development of preeclampsia or small for gestational age fetus, or even a malign neoplasia with a high risk of death.