VIGABATRIN IN THERAPY RESISTANT EPILEPSY - EFFICACY AND LONG-TERM FOLLOW-UP

被引：0

作者：

HAAN, J ^{[1
]}

KAUERZ, U ^{[1
]}

机构：

[1] UNIV HAMBURG,KRANKENHAUS EPPENDORF,NEUROL KLIN & POLIKLIN,W-2000 HAMBURG 20,GERMANY

来源：

AKTUELLE NEUROLOGIE | 1992年 / 19卷

关键词：

D O I：

10.1055/s-2007-1018081

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In 15 out of 39 patients (38.5 %) with therapy resistant epilepsies, vigabatrin add on led to an at least 50 % improvement of seizure frequency. The effectiveness was best in focal epilepsies. A loss of this effect was observed in 3 patients and in seven patients the treatment had to be discontinued - in spite of good therapeutic effect - because of severe side effects. These were especially observed in patients with proven brain lesions. Psychotic events only occured during the initial dosage finding phase. The long term follow-up (up to 64 months) showed a 50 to 100 % improvement in 12 out of 39 patients (30.8 %).

引用

页码：S52 / S53

页数：2