INDUCTION OF TYPE-I DIABETES BY INTERFERON-ALPHA IN TRANSGENIC MICE

被引：262

作者：

STEWART, TA ^{[1
]}

HULTGREN, B ^{[1
]}

HUANG, X ^{[1
]}

PITTSMEEK, S ^{[1
]}

HULLY, J ^{[1
]}

MACLACHLAN, NJ ^{[1
]}

机构：

[1] UNIV CALIF DAVIS,DEPT VET PATHOL,DAVIS,CA 95616

来源：

SCIENCE | 1993年 / 260卷 / 5116期

关键词：

D O I：

10.1126/science.8100367

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Type I diabetes is an autoimmune disease involving an interaction between an epigenetic event (possibly a viral infection), the pancreatic beta cells, and the immune system in a genetically susceptible host. The possibility that the type I interferons could mediate this interaction was tested with transgenic mice in which the insulin-producing beta cells expressed an interferon-alpha. These mice developed a hypoinsulinemic diabetes associated with a mixed inflammation centered on the islets. The inflammation and the diabetes were prevented with a neutralizing antibody to the interferon-alpha. Thus, the expression of interferon-alpha by the beta cells could be causal in the development of type I diabetes, which suggests a therapeutic approach to this disease.

引用

页码：1942 / 1946

页数：5

共 65 条

[1] INFLAMMATION BUT NOT AUTOIMMUNITY OCCURS IN TRANSGENIC MICE EXPRESSING CONSTITUTIVE LEVELS OF INTERLEUKIN-2 IN ISLET BETA-CELLS [J].