INDUCTION OF TYPE-I DIABETES BY INTERFERON-ALPHA IN TRANSGENIC MICE

被引：262
|
作者：
STEWART, TA [1 ]
HULTGREN, B [1 ]
HUANG, X [1 ]
PITTSMEEK, S [1 ]
HULLY, J [1 ]
MACLACHLAN, NJ [1 ]
机构：
[1] UNIV CALIF DAVIS,DEPT VET PATHOL,DAVIS,CA 95616
来源：
SCIENCE | 1993年 / 260卷 / 5116期
关键词：
D O I：
10.1126/science.8100367
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Type I diabetes is an autoimmune disease involving an interaction between an epigenetic event (possibly a viral infection), the pancreatic beta cells, and the immune system in a genetically susceptible host. The possibility that the type I interferons could mediate this interaction was tested with transgenic mice in which the insulin-producing beta cells expressed an interferon-alpha. These mice developed a hypoinsulinemic diabetes associated with a mixed inflammation centered on the islets. The inflammation and the diabetes were prevented with a neutralizing antibody to the interferon-alpha. Thus, the expression of interferon-alpha by the beta cells could be causal in the development of type I diabetes, which suggests a therapeutic approach to this disease.
引用
收藏
页码：1942 / 1946
页数：5
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