REGULATION OF ACETYLCHOLINE-RELEASE INVIVO FROM RAT HIPPOCAMPUS BY MONOAMINES AS REVEALED BY NOVEL COLUMN-SWITCHING HPLC WITH ELECTROCHEMICAL DETECTION

被引：30
|
作者：
OHUE, T
KOSHIMURA, K
AKIYAMA, Y
ITO, A
KIDO, T
TAKAGI, Y
MIWA, S
机构：
[1] KYOTO UNIV, FAC MED, DEPT PHARMACOL, KYOTO 606, JAPAN
[2] KYOTO UNIV, FAC MED, DEPT NEUROL, KYOTO 606, JAPAN
[3] KYOTO UNIV, FAC MED, DEPT NEUROSURG, KYOTO 606, JAPAN
来源：
BRAIN RESEARCH | 1992年 / 572卷 / 1-2期
关键词：
ACETYLCHOLINE RELEASE; HIPPOCAMPUS; BRAIN MICRODIALYSIS; NORADRENALINE; DOPAMINE; 5-HYDROXYTRYPTAMINE;
D O I：
10.1016/0006-8993(92)90497-W
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
To clarify monoaminergic regulation of acetylcholine (ACh) release in the rat hippocampus, the effects of administration of monoamines through a dialysis probe on extracellular ACh levels were examined using in vivo brain microdialysis combined with a novel column-switching HPLC system. Infusion of dopamine or 5-hydroxytryptamine, but not noradrenaline, increased ACh levels. The ACh levels also increased following infusion of apomorphine and 5-methoxy-N,N-dimethyltryptamine. These results demonstrate that hippocampal ACh release is regulated by dopamine and 5-hydroxytryptamine.
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页码：340 / 344
页数：5
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