PREPARATION OF OPTICALLY-ACTIVE KETONES VIA ENANTIOFACE-DIFFERENTIATING PROTONATION OF PROCHIRAL ENOLATES

被引：57

作者：

MATSUMOTO, K ^{[1
]}

OHTA, H ^{[1
]}

机构：

[1] KEIO UNIV,DEPT CHEM,YOKOHAMA,KANAGAWA 223,JAPAN

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 36期

关键词：

D O I：

10.1016/S0040-4039(00)92293-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enantioselective protonation of the prochiral lithium enolate (2) of 2-benzylcyclohexanone (3) was developed. Reaction of 2 with methyl (S)-alpha-hydroxyisocaproate (15) as a chiral proton source afforded (R)-3 in a high optical yield. This reaction is widely applicable to the preparation of various alpha-substituted optically active ketones.

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页码：4729 / 4732

页数：4

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