INFLUENCE OF ANTICHOLINERGIC TREATMENT ON RAT PANCREATIC PROTEIN AND AMYLASE CONCENTRATIONS

被引：3
作者：
EVANDER, A
IHSE, I
LUNDQUIST, I
机构：
[1] UNIV LUND, DEPT SURG, S-22185 LUND, SWEDEN
[2] UNIV LUND, DEPT PHARMACOL, S-22185 LUND, SWEDEN
来源：
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY | 1979年 / 14卷 / 01期
关键词：
Amylase; Anticholinergics; Pancreas; Protein; Rat;
D O I：
10.3109/00365527909179856
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Pancreatic protein and amylase concentrations were measured after s.c. administration of an anticholinergic drug (Pro-Banthine [propantheline (2-hydroxyethyl)diisopropyl-methyl-ammonium bromide xanthene-9-carboxylate]) to rats in different doses. In doses comparable to those given in acute pancreatitis an increase of both pancreatic protein and amylase concentrations was found. If pancreatitis is indeed caused or maintained by proteases released from the acinar cell, anticholinergics, giving rise to an accumulation of enzymes within the pancreas, may do more harm than good in the treatment of acute pancreatitis.
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页码：115 / 117
页数：3
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