Cardiac amyloidosis: A comprehensive review

被引：36
作者：
Fikrle, Michal [1 ]
Palecek, Tomas [1 ,3 ]
Kuchynka, Petr [1 ]
Nemecek, Eduard [1 ]
Bauerova, Lenka [2 ,4 ]
Straub, Jan [2 ,5 ]
Rysava, Romana [2 ,6 ]
机构：
[1] Charles Univ Prague, Fac Med 1, Dept Cardiovasc Med, Dept Med 2, U Nemocnice 2, Prague 12808 2, Czech Republic
[2] Gen Univ Hosp Prague, Prague, Czech Republic
[3] St Annes Univ Hosp Brno, Int Clin Res Ctr, Brno, Czech Republic
[4] Charles Univ Prague, Fac Med 1, Dept Pathol, Prague, Czech Republic
[5] Charles Univ Prague, Fac Med 1, Dept Hematol, Dept Med 1, Prague, Czech Republic
[6] Charles Univ Prague, Fac Med 1, Dept Nephrol, Prague, Czech Republic
来源：
COR ET VASA | 2013年 / 55卷 / 01期
关键词：
Amyloidosis; Cardiomyopathy; Heart failure; Diagnosis; Imaging; Treatment;
D O I：
10.1016/j.crvasa.2012.11.018
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Cardiac amyloidosis is characterized by clinically significant extracellular amyloid infiltration of the heart that is usually, but not always, associated with the involvement of other organs depending on the type of amyloid. Cardiac involvement represents the most important prognostic factor especially in AL amyloidosis and thus early diagnosis of amyloid heart disease is of utmost importance influencing further management of the patients. This review aims to broadly discuss pathogenesis, manifestation and complex diagnostics of amyloidosis with the main focus on amyloid cardiomyopathy. Also, the summary of current therapeutic options that have great potential to improve existing poor prognosis of affected individuals is given. (C) 2012 The Czech Society of Cardiology. Published by Elsevier Urban & Partner Sp.zo.o. All rights reserved.
引用
收藏
页码：E60 / E75
页数：16
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