HERITABLE TRANSLOCATIONS INDUCED BY INHALATION EXPOSURE OF MALE-MICE TO 1,3-BUTADIENE

被引：22

作者：

ADLER, ID ^{[1
]}

FILSER, JG ^{[1
]}

GASSNER, P ^{[1
]}

KESSLER, W ^{[1
]}

SCHONEICH, J ^{[1
]}

SCHRIEVERSCHWEMMER, G ^{[1
]}

机构：

[1] GSF FORSCHUNGSZENTRUM UNWELT & GESUNDHEIT GMBH,INST TOXICOL,D-85758 OBERSCHLEISSHEIM,GERMANY

来源：

MUTATION RESEARCH LETTERS | 1995年 / 347卷 / 3-4期

关键词：

BUTADIENE; HERITABLE TRANSLOCATION; MOUSE;

D O I：

10.1016/0165-7992(95)00030-5

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Previously, we reported that dominant lethal mutations were induced in spermatids after inhalation exposure of male (102/El X C3H/El)F-1 mice to 1300 ppm of 1,3-butadiene on 5 days for 6 h per day (exposure dose 39 000 ppm h). The same inhalation exposure was given to male C3H/El inbred mice which were mated to inbred line 102/El females 8-14 d after the end of exposure. Male and female F-1 hybrid progeny were tested for the presence of heritable translocations by observation of litter sizes and by cytogenetic analyses in meiotic and somatic cells. 1,3-Butadiene induced heritable translocations in late spermatids. The translocation frequency after 1,3-butadiene exposure to 39 000 ppm h was 2.7% (16 translocation heterozygotes among 599 F-1 offspring). This frequency is 54 times higher than the historical control frequency (0.05%; 5 translocation heterozygotes among 9500 F-1 offsping). Thus, 1,3-butadiene causes heritable germ cell effects in mice.

引用

页码：121 / 127

页数：7

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