IMMEDIATE HYPERSENSITIVITY REACTION TO CYCLOPHOSPHAMIDE

被引：6

作者：

KNYSAK, DJ ^{[1
]}

MCLEAN, JA ^{[1
]}

SOLOMON, WR ^{[1
]}

FOX, DA ^{[1
]}

MCCUNE, WJ ^{[1
]}

机构：

[1] UNIV MICHIGAN,CTR MED,DEPT INTERNAL MED,DIV ALLERGY,ANN ARBOR,MI 48109

来源：

ARTHRITIS AND RHEUMATISM | 1994年 / 37卷 / 07期

关键词：

D O I：

10.1002/art.1780370717

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report a case of an acute anaphylactic reaction to intravenous cyclophosphamide in a patient with systemic lupus erythematosus. Skin testing for reactivity to cyclophosphamide and one of its metabolites, 4-hydroperoxycyclophosphamide, was performed on the patient and on 6 controls. The patient exhibited positive skin test responses; all controls had negative responses. The results suggest an acute hypersensitivity reaction related to sensitivity to cyclophosphamide and to 4-hydroperoxycyclophosphamide, through a shared antigenic determinant or dual sensitization.

引用

页码：1101 / 1104

页数：4

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