IMMEDIATE HYPERSENSITIVITY REACTION TO CYCLOPHOSPHAMIDE

被引：6
|
作者：
KNYSAK, DJ [1 ]
MCLEAN, JA [1 ]
SOLOMON, WR [1 ]
FOX, DA [1 ]
MCCUNE, WJ [1 ]
机构：
[1] UNIV MICHIGAN,CTR MED,DEPT INTERNAL MED,DIV ALLERGY,ANN ARBOR,MI 48109
来源：
ARTHRITIS AND RHEUMATISM | 1994年 / 37卷 / 07期
关键词：
D O I：
10.1002/art.1780370717
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We report a case of an acute anaphylactic reaction to intravenous cyclophosphamide in a patient with systemic lupus erythematosus. Skin testing for reactivity to cyclophosphamide and one of its metabolites, 4-hydroperoxycyclophosphamide, was performed on the patient and on 6 controls. The patient exhibited positive skin test responses; all controls had negative responses. The results suggest an acute hypersensitivity reaction related to sensitivity to cyclophosphamide and to 4-hydroperoxycyclophosphamide, through a shared antigenic determinant or dual sensitization.
引用
收藏
页码：1101 / 1104
页数：4
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