INFLUENCE OF DPPE ON HISTAMINE-RELEASE FROM ISOLATED RAT MAST-CELLS

被引：1

作者：

GROSMAN, N

机构：

[1] Department of Pharmacology, The Panum Institute, University of Copenhagen, Copenhagen N, DK-2200

来源：

AGENTS AND ACTIONS | 1994年 / 41卷 / 1-2期

关键词：

DPPE; HISTAMINE RELEASE; MAST CELLS;

D O I：

10.1007/BF01986384

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A second messenger function for histamine has been proposed based on the effects of the anti-estrogen drug DPPE (N,N-diethyl-2-(4-(phenylmethyl)phenoxy) ethanamine.HCl). The ability of DPPE to inhibit concanavalin A-induced histamine release led to the present investigation of its influence on the mast cell. response to a wider selection of secretagogues. DPPE was an efficient inhibitor of antigen-induced release, while responses to compound 48/80 were virtually unaffected. Responses to the ionophore A23187 could be enhanced as well as inhibited, whereas the influence of DPPE on the combination of the ionophore and the phorbol ester TPA was variable and small. These results seem to exclude an involvement of a DPPE-sensitive histamine-mediated signal system of common importance in mast cell histamine release.

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页码：1 / 4

页数：4

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