TOTAL CHOLESTEROL, HIGH-DENSITY-LIPOPROTEIN CHOLESTEROL, AND TRIGLYCERIDES IN CHILDREN RECEIVING ANTIEPILEPTIC DRUGS

被引：60

作者：

FRANZONI, E ^{[1
]}

GOVONI, M ^{[1
]}

DADDATO, S ^{[1
]}

GUALANDI, S ^{[1
]}

SANGIORGI, Z ^{[1
]}

DESCOVICH, GC ^{[1
]}

SALVIOLI, GP ^{[1
]}

机构：

[1] UNIV BOLOGNA,LIPID CLIN,I-40138 BOLOGNA,ITALY

来源：

EPILEPSIA | 1992年 / 33卷 / 05期

关键词：

TOTAL CHOLESTEROL; ANTICONVULSANTS; CHILDREN; DIET TREATMENT; DRUG TOXICITY;

D O I：

10.1111/j.1528-1157.1992.tb02203.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The influence of antiepileptic drug (AED) therapy on total cholesterol (TC), high-density lipoprotein (HDL) cholesterol, and triglycerides was studied in 208 epileptic children compared with 175 normal children. A significant increase in TC plasma levels was observed with carbamazepine (CBZ), phenobarbital (PB), and phenytoin (PHT). The patients receiving valproate (VPA) showed levels very similar to those of the control population. The results may be explainable by the different biotransformation pathway of these drugs. HDL cholesterol and triglycerides were not altered by any of the AEDs. We recommend monitoring TC level in patients receiving CBZ, PB, and PHT and prescription of diet treatment, at least during the time of AED treatment.

引用

页码：932 / 935

页数：4

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