TOTAL CHOLESTEROL, HIGH-DENSITY-LIPOPROTEIN CHOLESTEROL, AND TRIGLYCERIDES IN CHILDREN RECEIVING ANTIEPILEPTIC DRUGS

被引：60
|
作者：
FRANZONI, E [1 ]
GOVONI, M [1 ]
DADDATO, S [1 ]
GUALANDI, S [1 ]
SANGIORGI, Z [1 ]
DESCOVICH, GC [1 ]
SALVIOLI, GP [1 ]
机构：
[1] UNIV BOLOGNA,LIPID CLIN,I-40138 BOLOGNA,ITALY
来源：
EPILEPSIA | 1992年 / 33卷 / 05期
关键词：
TOTAL CHOLESTEROL; ANTICONVULSANTS; CHILDREN; DIET TREATMENT; DRUG TOXICITY;
D O I：
10.1111/j.1528-1157.1992.tb02203.x
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The influence of antiepileptic drug (AED) therapy on total cholesterol (TC), high-density lipoprotein (HDL) cholesterol, and triglycerides was studied in 208 epileptic children compared with 175 normal children. A significant increase in TC plasma levels was observed with carbamazepine (CBZ), phenobarbital (PB), and phenytoin (PHT). The patients receiving valproate (VPA) showed levels very similar to those of the control population. The results may be explainable by the different biotransformation pathway of these drugs. HDL cholesterol and triglycerides were not altered by any of the AEDs. We recommend monitoring TC level in patients receiving CBZ, PB, and PHT and prescription of diet treatment, at least during the time of AED treatment.
引用
收藏
页码：932 / 935
页数：4
相关论文
共 50 条
  • [21] EGG CONSUMPTION AND HIGH-DENSITY-LIPOPROTEIN CHOLESTEROL
    SCHNOHR, P
    THOMSEN, OO
    HANSEN, PR
    BOBERGANS, G
    LAWAETZ, H
    WEEKE, T
    JOURNAL OF INTERNAL MEDICINE, 1994, 235 (03) : 249 - 251
  • [22] DISTRIBUTIONS OF TOTAL CHOLESTEROL, TRIGLYCERIDES, AND HIGH-DENSITY-LIPOPROTEIN CHOLESTEROL IN ISRAELI JEWISH CHILDREN OF DIFFERENT GEOGRAPHIC-ETHNIC ORIGINS, AGES 9-17 YEARS
    ZAHAVI, I
    GOLDBOURT, U
    COHENMANDELZWEIG, L
    KATZ, M
    APPEL, S
    HAREL, G
    SPERLING, Z
    LAZAROVICI, M
    HART, J
    NEUFELD, HN
    PREVENTIVE MEDICINE, 1987, 16 (01) : 35 - 51
  • [23] A RELATION BETWEEN HIGH-DENSITY-LIPOPROTEIN CHOLESTEROL AND BILE CHOLESTEROL SATURATION
    THORNTON, JR
    HEATON, KW
    MACFARLANE, DG
    BRITISH MEDICAL JOURNAL, 1981, 283 (6303): : 1352 - 1354
  • [24] EFFECTS OF PHENYTOIN ON PLASMA HIGH-DENSITY-LIPOPROTEIN CHOLESTEROL LEVELS IN MEN WITH LOW-LEVELS OF HIGH-DENSITY-LIPOPROTEIN CHOLESTEROL
    GOERDT, C
    KEITH, M
    RUBINS, HB
    JOURNAL OF CLINICAL PHARMACOLOGY, 1995, 35 (08): : 767 - 775
  • [25] THE RELATION OF DOCUMENTED CORONARY-ARTERY DISEASE TO LEVELS OF TOTAL CHOLESTEROL AND HIGH-DENSITY-LIPOPROTEIN CHOLESTEROL
    FREEDMAN, DS
    CROFT, JB
    ANDERSON, AJ
    BYERS, T
    JACOBSEN, SJ
    GRUCHOW, HW
    WALKER, JA
    BARBORIAK, JJ
    EPIDEMIOLOGY, 1994, 5 (01) : 80 - 87
  • [26] THE ASSOCIATION BETWEEN PLASMA-CHOLESTEROL, HIGH-DENSITY-LIPOPROTEIN CHOLESTEROL, TRIGLYCERIDES AND URIC-ACID IN ETHANOL CONSUMERS
    ALLEN, JK
    ADENA, MA
    ANNALS OF CLINICAL BIOCHEMISTRY, 1985, 22 (JAN) : 62 - 66
  • [27] EFFECT OF SAMPLE STORAGE ON THE MEASUREMENT OF LIPOPROTEIN[A], APOLIPOPROTEIN-B AND APOLIPOPROTEIN-A-IV, TOTAL AND HIGH-DENSITY-LIPOPROTEIN CHOLESTEROL AND TRIGLYCERIDES
    KRONENBERG, F
    LOBENTANZ, EM
    KONIG, P
    UTERMANN, G
    DIEPLINGER, H
    JOURNAL OF LIPID RESEARCH, 1994, 35 (07) : 1318 - 1328
  • [28] CONCENTRATIONS OF HIGH-DENSITY LIPOPROTEIN CHOLESTEROL, TRIGLYCERIDES, AND TOTAL CHOLESTEROL IN ISCHEMIC HEART-DISEASE
    POCOCK, SJ
    SHAPER, AG
    PHILLIPS, AN
    BMJ-BRITISH MEDICAL JOURNAL, 1989, 298 (6679): : 998 - 1002
  • [29] HIGH-DENSITY-LIPOPROTEIN CHOLESTEROL AND TRIGLYCERIDES AS MARKERS OF ANGIOGRAPHICALLY ASSESSED CORONARY-ARTERY DISEASE
    NIKKILA, M
    KOIVULA, T
    NIEMELA, K
    SISTO, T
    BRITISH HEART JOURNAL, 1990, 63 (02): : 78 - 81
  • [30] PHYSICAL-ACTIVITY AND HIGH-DENSITY-LIPOPROTEIN CHOLESTEROL
    HARTUNG, GH
    JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS, 1995, 35 (01): : 1 - 5
12345