MECHANISM OF DECOMPOSITION OF N-HYDROXYACETAMINOPHEN, A POSTULATED TOXIC METABOLITE OF ACETAMINOPHEN

被引：28
作者：
GEMBORYS, MW
MUDGE, GH
GRIBBLE, GW
机构：
[1] DARTMOUTH COLL,SCH MED,DEPT MED,HANOVER,NH 03755
[2] DARTMOUTH COLL,DEPT CHEM,HANOVER,NH 03755
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 1980年 / 23卷 / 03期
关键词：
D O I：
10.1021/jm00177a019
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
引用
收藏
页码：304 / 308
页数：5
相关论文
共 26 条
[1]   REACTIONS OF N-ACETOXYPHENACETIN - AN INVITRO MODEL FOR METABOLISM OF PHENACETIN [J].
CALDER, IC ;
CREEK, MJ .
AUSTRALIAN JOURNAL OF CHEMISTRY, 1976, 29 (08) :1801-1808
[2]  
CALDER IC, 1978, BIOL OXIDATION NITRO, P309
[3]  
CALDER IC, COMMUNICATION
[4]  
FINLEY KT, 1974, CHEM QUINONOID COMPO, pCH17
[5]   5-METHOXYLATION OF OXINDOLE DERIVATIVES [J].
GASSMAN, PG ;
CAMPBELL, GA .
JOURNAL OF THE CHEMICAL SOCIETY D-CHEMICAL COMMUNICATIONS, 1971, (22) :1437-&
[6]   SYNTHESIS OF N-HYDROXYACETAMINOPHEN - POSTULATED TOXIC METABOLITE OF ACETAMINOPHEN, AND ITS PHENOLIC SULFATE CONJUGATE [J].
GEMBORYS, MW ;
GRIBBLE, GW ;
MUDGE, GH .
JOURNAL OF MEDICINAL CHEMISTRY, 1978, 21 (07) :649-652
[7]  
GERBER JG, 1977, LANCET, V1, P657
[8]   LIVER AND KIDNEY DAMAGE INDUCED BY N-HYDROXYPARACETAMOL [J].
HEALEY, K ;
CALDER, IC ;
YONG, AC ;
CROWE, CA ;
FUNDER, CC ;
HAM, KN ;
TANGE, JD .
XENOBIOTICA, 1978, 8 (07) :403-411
[9]   N-HYDROXYACETAMINOPHEN - MICROSOMAL METABOLITE OF N-HYDROXYPHENACETIN BUT APPARENTLY NOT OF ACETAMINOPHEN [J].
HINSON, JA ;
POHL, LR ;
GILLETTE, JR .
LIFE SCIENCES, 1979, 24 (23) :2133-2138
[10]   N-HYDROXYLATION OF PARA-CHLOROACETANILIDE IN HAMSTERS [J].
HINSON, JA ;
MITCHELL, JR ;
JOLLOW, DJ .
BIOCHEMICAL PHARMACOLOGY, 1976, 25 (05) :599-601
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